Oncogenicity of AKR endogenous leukemia viruses
نویسندگان
چکیده
منابع مشابه
Immunopathogenicity and Oncogenicity of Murine Leukemia Viruses
This report clearly demonstrates that a systemic lupus erythematosus (SLE)-like syndrome and lymphoma can be induced in immunologically normal (BALB/c x NZB)F(1) mice by infection of neonates with a murine leukemia virus (MuLV) (Scripps leukemia virus [SLV] 60A) isolated from NZB lymphoblasts. SLV 60A was titered in vitro (XC test) and administered to newborn and adult (BALB/c x NZB)F(1) mice o...
متن کاملA discrepancy in XC and oncogenicity assays for murine leukemia virus in AKR mice.
Studies of murine leukemia virus expression in AKR mice are presented. Material from in vivo and in vitro sources of normal tissues and lymphomas was assayed for in vitro infectivity, using the XC plaque assay, and for oncogenicity, by assessing lymphoma-accelerating capacity after inoculation into newborn animals. Normal tissues from healthy young AKR mice up to 7 months of age were found to h...
متن کاملIncreased oncogenicity of the murine sarcoma virus (Moloney) by co-infection with murine leukemia viruses.
The high incidence of spontaneous regressions of primary tu mors induced by the Moloney sarcoma virus in adult mice was significantly altered by co-infection with Rauscher, Moloney, and Friend leukemia viruses. Intramuscular, intraperitoneal, or subcutaneous inoculation of sarcoma extracts, prepared from progressively growing tumors obtained from dually infected animals, resulted in extensive m...
متن کاملGenomically intact endogenous feline leukemia viruses of recent origin.
We isolated and sequenced two complete endogenous feline leukemia viruses (enFeLVs), designated enFeLV-AGTT and enFeLV-GGAG. In enFeLV-AGTT, the open reading frames are reminiscent of a functioning FeLV genome, and the 5' and 3' long terminal repeat sequences are identical. Neither endogenous provirus is genetically fixed in cats but polymorphic, with 8.9 and 15.2% prevalence for enFeLV-AGTT an...
متن کاملMurine Leukemia Virus Antigens in Akr
It is now well established that viruses of the murine leukemia virus (MuLV)' group are present ifi all m i ~ (1, 2) and that viral genetic sequences are present as chromosomal DNA (3-5). The expression of this genetic material, as virus particles or viral antigens, differs markedly between strains of mice, both with regard to the age at which the expression occurs (6-8) and the spectrum of biol...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Virology
سال: 1978
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.27.1.13-18.1978